4-FEA is structurally related to a series of designer fluorinated substituted amphetamines that originally included compounds such as 2-FA, 2-FMA, 3-FA, 4-FMA, 4-FA.
4-FEA has been reported to be sold as a designer drug, but little is known about its pharmacology or toxicology.It was first detected from legal highs sold in Japan in 2006 and became illegal to sell or to possess for the purpose of distribution (although not to simply possess for personal use) in Japan in 2008.It was initially reported to be contained as an ingredient in some of the range of party pills sold internationally by the Israeli company Neorganics from around 2006 onwards, but this was later shown to be incorrect and this ingredient was eventually identified as the closely related compound 2-fluoromethamphetamine.
4-FEA is a synthetic molecule of the amphetamine chemical class. Molecules of the amphetamine class contain a phenethylamine core comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain substituted with a methyl group at Rα (i.e. amphetamines are alpha-methylated phenethylamines).
4-FEA is the 4-position fluorinated analog of ethylamphetamine (also known as ethamphetamine). It is also an analog of fenfluramine with the 3-trifluoromethyl group replaced with a 3-fluoro substituent.
4-FEA has an extremely short history of human recreational use and has not been documented being sold on the streets. It has recently been made available for sale on the grey market as a research chemical by online vendors.Due to its potent psychostimulant effects, likely habit-forming properties, and unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using this substance.
4-FEA is structurally related to a series of designer fluorinated substituted am that originally included compounds such as 4-FMA .This product is intended for forensic and research purposes.
Although 4-FEA has not been formally studied on the same level as traditional amphetamines, it is currently assumed that like other substituted amphetamines with substitutions at similar positions, it most likely acts primarily as a triple reuptake inhibitor and/or releaser of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine.
It has been demonstrated that compared to the unsubstituted ethylamphetamine, 4-fluoroethamphetamine is a weaker releaser of dopamine, but a stronger releaser of both serotonin and norepinephrine, producing the strongest reinforcing effects in animal studies out of a range of 3-substituted amphetamine derivatives tested, despite not being the most potent dopamine releaser.
Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
Stimulants – 4-FEA can be potentially dangerous in combination with other stimulants as it increase one’s heart rate and blood pressure to dangerous levels.
25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM – This combination may cause increased heart rate and panic attacks.
MXE – Increased heart rate and blood pressure may occur.
Tramadol – This combination can increase the risk of seizures.
MDMA – The neurotoxic effects of MDMA may be increased when combined with other amphetamines or monoamine releasing agents.
Cocaine – This combination may increase strain on the heart to dangerous levels.